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  • An analysis of the structual binding and potency of vascular endothelial growth factor receptor (VEGFR) inhibitors indicates that the inclusion of interactions with the juxtamemebrane domain better reflects the efficacy of these drugs in renal cell carcinoma.

    • Charlotte Harrison
    Research Highlight

  • Mitochondrial defects in cells expressing oncogenic RASV12can induce surrounding cells to proliferate owing to effects on the Hippo pathway.

    • Nicola McCarthy
    Research Highlight

  • A new mouse model of adoptive cell transfer for the treatment of melanoma indicates that dedifferentiation of melanoma cells, driven by an inflammatory response, might have a role in resistance.

    • Nicola McCarthy
    Research Highlight

  • A new study characterizes metabolic roles for the tumour suppressing TAp63 isoforms of p63.

    • Darren J. Burgess
    Research Highlight

  • A pathway in which alternative splicing of histone variant isoforms regulates transcription of redox metabolism genes has been shown to have a role in tumour cell invasion and might be relevant in human breast cancer.

    • Sarah Seton-Rogers
    Research Highlight

  • Reactive aldehydes generated by metabolism may contribute to the pathogenesis of Fanconi anaemia.

    • Nicola McCarthy
    Research Highlight

  • A new study shows that disruptions to a DNA modification in melanoma may hold diagnostic and therapeutic promise.

    • Darren J. Burgess
    Research Highlight

  • Is the transcription factor MYC an amplifier of gene transcription?

    • Nicola McCarthy
    Research Highlight

  • Two papers published inCancer Cellhave examined the role of epidermal growth factor receptor signalling in KRAS-driven pancreatic tumorigenesis.

    • Sarah Seton-Rogers
    Research Highlight

  • Two papers report that combined inhibition of PI3K and poly(ADP) ribose polymerase (PARP) is synergistic in BRCA1-defective and BRCA-proficient triple-negative breast cancer.

    • Gemma K. Alderton
    Research Highlight

  • Reactivation of dormant breast cancer cells at metastatic sites may require these cells to overcome organ-specific suppressive signals in the microenvironment and to activate stem cell-like traits.

    • Sarah Seton-Rogers
    Research Highlight

  • A new study characterizes the molecular events underlying cancer-associated stromal remodelling.

    • Darren J. Burgess
    Research Highlight

  • Two recently published papers examine the metabolic and nonmetabolic functions of PKM2 in greater detail.

    • Nicola McCarthy
    Research Highlight