News & Comment

Canine tumours steal mitochondria from their hosts.

Three papers report the involvement of SLX4 in the Fanconi anaemia DNA repair pathway, and two papers show that mutations inSLX4cause a new subtype of Fanconi anaemia.

A new study identifies four genes as drivers of PCA progression and as a signature with prognostic value for predicting the risk of developing metastatic PCA.

Exposure of mouse skin to UVB early in life generates macrophage infiltration and an interferon-γ response that promotes melanocytic survival, evasion of the immune response and oncogenesis.

The cancer stem cell marker CD44 is a target of the tumour suppressive microRNA, miR-34a.

Two new studies uncover unexpected genetic complexities in leukaemia-initiating cell populations.

A new algorithm that combines gene expression and copy number alterations to identify driver genes and their possible function is reported. This was applied to melanoma samples, and vesicular trafficking was found to be an important process in this type of cancer.

A new phenomenon in which tens to hundreds of genomic rearrangements are acquired in one step has been identified.

The RAC-GEF PREX1 integrates signals from tyrosine kinase receptors and GPCRs to activate RAC1.

This Science and Society article discusses the major issues regarding cancer-related direct-to-consumer advertising (DTCA) and offers data from the United States as an illustration of communication inequalities in this arena — highlighting the need for closer and continuing attention to the issue of DTCA in the age of internet-based information and genomic revolution.

Medulloblastomas with a mutation in the Wnt pathway arise from cells that are distinct from those affected by mutations in the SHH pathway.

The Hippo pathway couples cell polarity complexes to extrinsic signalling pathways.

A new study identifies a regulatory mechanism controlling carbon source uptake.