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Three papers show that hepatocyte growth factor (HGF)–MET signalling is an important determinant of therapeutic responses and can be induced through paracrine, autocrine and endocrine production of HGF.
A paper published inNature Physicshas experimentally and mathematically modelled epithelial cell migration and identified mechanically generated waves that are important for cellular motility.
Two papers show that KRAS-G12D-transformed pancreatic tumour cells produce GM-CSF, which recruits MDSCs to promote an immunosuppressive microenvironment.
Wigard Kloosterman, Edwin Cuppen and colleagues have evidence that chromothripsis might arise owing to clustered DNA double-strand breaks (DSBs) and nonhomologous repair mechanisms.
Knockout of the Notch effectorRbpjkin mesenchymal fibroblasts enhances the formation of squamous cell carcinomas of the skin in mice, and similar changes can be induced by exposure of human skin to ultraviolet A irradiation.
This paper suggests that recurrent regions of somatic hemizygosity might exist in tumours because they enable a reduction in the expression levels of genes that restrict cell proliferation and survival, and minimize the loss of genes that are essential for cell survival.
Gordenin and colleagues analyse the clustering of mutations in cancer genomes and identify a subfamily of APOBECs as a possible cause of mutation clustering.
Liuet al. have identified MYC as a suppressor of metastasis, cell motility and invasion, and provide evidence that this newly uncovered role is dependent on the αv and β3 integrin extracellular matrix receptors.