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On the basis of personal experiences and in light of current US socio-political realities, Eric Lau advocates for proactive actions against discrimination and emphasizes the need to speak out against oppression, urging research institutions to prioritize diversity, equity and inclusion.
In this Tools of the Trade article, Chiara Cattaneo describes the development of HANSolo, a high-throughput genetic platform for the personalized identification of CD4+ and CD8+ T cell-recognized (neo)antigens, that can be used to generate patient-specific TCR gene therapies or cancer vaccines.
In this Tools of the Trade article, Emmanuel Olivier describes an approach to reprogramming AML cancer cells into induced pluripotent stem cells, which provide faithful genetic models of the most common genetic subgroups of AML.
Although sometimes overlooked, storytelling is a powerful tool for communicating scientific research. In this World View, Julia Bauman outlines what is needed to convey a strong scientific narrative, gleaned from her experience making 60-second TikTok videos summarizing published research papers.
Rahme et al. establish an in vivo model for low-grade glioma, and use it to demonstrate that Pdgfra insulator loss and Cdkn2a promoter silencing are epigenetic drivers of gliomagenesis.
Bland et al. show that cancer types with heterozygous somatic hotspot mutations in the spliceosome component SF3B1 are vulnerable to PARP inhibition, which causes a defective response to replication stress.
Two independent studies published together in Nature find that AT1 cells can have a role in both the initiation and suppression of lung adenocarcinoma.
In this Tools of the Trade article, Yuan Ma describes the development and use of ARPLA, a spatial imaging tool that can be used to visualize glycoRNAs in single cells, including cancer cells in situ.
Girish et al. designed a method to genetically remove extra chromosomes from human aneuploid cancer cells to show that they are important for malignant growth and not just a bystander.
Inducing ferroptosis in cancer cells has become a realistic method for promoting cancer cell death. In this study, Nakarmua et al. identify a novel ferroptosis suppressor 1 (FSP1) inhibitor that promotes FSP1 relocalization through phase separation, priming ferroptosis and ultimately impairing tumour growth.
Two independent studies published in Nature have collectively addressed the long-standing question of sex bias in cancer and implicated non-hormonal genes of the Y chromosome in aggressive features of colorectal and bladder cancers in men.
In this study, Malladi and colleagues reveal the mechanism by which mitochondrial fragmentation enables latent brain metastatic breast cancer cells to increase fatty acid oxidation to maintain cellular energetics and redox homeostasis.
In this Tools of the Trade article, Ciaran Seath describes the development and use of a proximity labelling method to study how cancer driving mutations and small molecule ligands remodel the chromatin microenvironment.
Wang et al. demonstrate how tumour-derived extracellular vesicles and particles dysregulate liver function to promote fatty liver disease and diminish chemotherapeutic efficacy.
In this Tools of the Trade article, Isabel Esain-Garcia describes the development and use of a 6-letter whole-genome sequencing technology, which enables the simultaneous acquisition of genetic and epigenetic information from human genomic and cell-free DNA, which has implications for improving our biological understanding of cancer as well as cancer diagnosis and early intervention.
