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A recentNaturepaper identifies a catabolite of tryptophan as an endogenous ligand of aryl hydrocarbon receptor and links this pathway to tumorigenesis and suppression of antitumour immunity.
Daley and colleagues show that LIN28-mediated suppression of let-7 microRNAs activates the insulin–PI3K–mTOR pathway to regulate glucose metabolism, connecting type 2 diabetes and cancer.
Bradner, Mitsiades and colleagues show that inhibition of BET family proteins with the small-molecule inhibitor JQ1 selectively represses the expression ofMYC,and MYC and E2F1 target genes.