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It has been nearly 100 years since Francis Peyton Rous proved that sarcomatous chest tumours in Plymouth Rock hens could be caused by a virus. Since then, seven human viruses have been found to cause 10–15% of human cancers. This Timeline article explores the different techniques that helped in identifying these viruses, the common features they share and the different ways they evade innate immunity and cause cancer.
Proteomics approaches to characterize various aspects of cancer have increased as technology has improved. What are the challenges to cancer proteomics research and what could the future hold?
The four colony-stimulating factors (CSFs) regulate the generation and some functions of granulocytes and macrophages, and recombinant granulocyte-CSF and granulocyte–macrophage-CSF are used to treat patients with reduced white blood cell levels. How did we come to our understanding of the CSFs and what might the future opportunities be?
This Timeline article charts progress in mathematical modelling of cancer over the past 50 years, highlighting the different theoretical approaches that have been used to dissect the disease and the insights that have arisen.
This Timeline article looks back over 50 years of haematopoietic stem cell transplantation as a cancer therapy, highlighting the substantial advances that have been made to increase the specificity of this treatment for cancer cells, as well as improvements in availability, safety and patient outcomes.
