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This article discusses the possible function of the super elongation complex (SEC) and the DOT1 H3K79 methyltransferase complex (DotCom) in leukaemia that is induced by translocation of mixed lineage leukaemia (MLL).
Over the past 40 years, genetic studies have provided important insights into the genetic architecture of common cancers. Recent genome-wide studies have identified numerous cancer susceptibility genes and led to a shift from single-gene models to multigenic models of cancer risk.
