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Paolinoet al. have shown that deletion or inhibition of casitas B-lineage lymphoma-b (Cbl-b) decreases metastasis in various mouse tumour models by activating natural killer cells.
This Review describes some of the latest techniques that are being used to discover modulators of protein–protein interactions and how current drug discovery approaches have been adapted to successfully target these interfaces.
John Dick and colleagues have found that pre-leukaemic haematopoietic stem cells (HSCs) are present in patients with acute myeloid leukaemia. These cells contain clinically relevant mutations but can act as functional HSCs and undergo multilineage differentiation. Furthermore, these cells seem to be resistant to chemotherapy and could contribute to relapse.
The early detection and prevention of childhood cancer is an important area of cancer research. In this Opinion article, the authors argue that identifying whether some childhood cancers arise from an aberrant prenatal cell population could help with disease prevention.
Two papers have found that high-grade bladder cancer can be spilt into several subtypes, including luminal and basal subtypes, which match these subtypes in breast cancer.
Zhuet al. identified mutations in the histone-lysine N-methyltransferase SETD2and showed that these mutations cooperate with other genetic aberrations to promote acute leukaemia.
Examination of DNA cytosine methylation during haematopoietic stem cell differentiation identified an epigenetic stem cell commitment signature that was prognostic for overall survival in patients with acute myeloid leukaemia.
Charles Keller and colleagues have found that a higher expression of PAX3–FOXO1A during G2/M phase is permissive for G2 checkpoint adaptation in rhabdomyosarcoma.
