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Age is the main risk factor of neurodegenerative diseases, but environmental exposure and lifestyle are important candidates for understanding their etiology. Accumulating evidence suggests that “exposome”, described as the totality of human environmental exposures from conception onwards, represents major modifiable risk factors for most neurodegenerative diseases and dementia. In this commentary, we discuss and provide our opinion about the urgent need for a constructive dialog between political stakeholders, researchers, and physicians to implement specific strategies to counteract and reduce the onset of neurodegenerative diseases.
