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Volume 4 Issue 8, August 2019

Volume 4 Issue 8

Sticking together

Direct interaction of influenza virus with Gram-positive and Gram-negative bacterial pathogens of the respiratory tract results in increased bacterial adherence to respiratory epithelial cells in culture and in higher bacterial burdens in vivo.

See Rowe, H. M. et al.

Image: Jason Rosch, Hannah Rowe and Aaron Pitre. Cover Design: Lauren Heslop.

Editorial

  • Editorial |

    Faecal microbiota transplantation can efficiently treat recurring Clostridioides difficile infection and is being investigated for other indications. However, strict quality control of the donor stool is necessary to avoid putting patients at unnecessary risk.

News & Views

  • News & Views |

    Host cells assemble linear ubiquitin chains to activate immune signalling during bacterial infection. A new study reveals that Legionella pneumophila — the causative agent of Legionnaires’ disease — produces an enzyme that specifically disassembles these linear ubiquitin modifications to restrict immune responses.

    • Rune Busk Damgaard
    • Jonathan N. Pruneda
  • News & Views |

    The finding that the two cell wall elongation systems of Bacillus subtilis have opposite effects on cell diameter and on the amount of oriented material along the sidewalls elucidates the long-standing question of how cell width is controlled in rod-shaped bacteria.

    • Rut Carballido-López
  • News & Views |

    Complementary genomic frameworks for taxonomic classification of viruses infecting bacteria and archaea reveal evolutionary drivers, mosaicism and perspective on the genetic diversity of the tiniest, most abundant biological entities on Earth.

    • Emiley A. Eloe-Fadrosh
  • News & Views |

    There is increasing evidence of direct and/or indirect interactions between bacteria and viruses. Two new studies shed light on the mechanisms underlying these interactions with implications not only for our understanding of microbial pathogenesis, but also for vaccine design.

    • Karl J. Staples

Reviews

  • Review Article |

    This Review summarizes mathematical modelling approaches that can be applied to microbiome datasets, providing insights into microbial dynamics and interactions in this complex system.

    • Manish Kumar
    • Boyang Ji
    • Jens Nielsen

Research

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