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Chemotaxis towards the interspecies quorum sensing signal autoinducer 2 (AI-2) promotes gut colonization by Escherichia coli and is linked to fructoselysine metabolism. The differential ability of E. coli strains to chemotactically respond to AI-2 further leads to niche segregation and co-existence of E. coli strains in the murine gut.
A combined quantitative and isotope-tracking proteomics approach illuminates how scarce nitrogen is allocated to protein biosynthesis by members of an ocean-surface microbial community. We identify taxon-specific substrate preferences and a distinct subset of functions — particularly infrastructure for protein production, folding and turnover — that constitute the bulk of community nitrogen demand.
An argument for how anaerobic eukaryotes have maintained cellular complexity over evolutionary time, despite reliance on the low energy-yielding fermentation.
‘Candidatus Methanoperedens nitroreducens’, an anaerobic methanotrophic archaeon, sectors itself into two morphologically and functionally distinct populations that enable adaptation and cross-species interactions in a dynamic bioreactor ecosystem.
New World arenaviruses are pathogens capable of zoonotic infections that cause viral haemorrhagic fevers, which are frequently lethal in humans. However, a recombinant live-attenuated pentavalent vaccine shows promising efficacy against infection.
This work shows that Akkermansia muciniphila and its metabolite, harmaline, upregulate the production of bile acid-coenzyme A: amino acid N-acyltransferase (BAAT) in hepatocytes. As a result of enhanced BAAT production, increased synthesis of conjugated primary bile acids suppresses the severe systemic inflammation caused by severe fever with thrombocytopenia syndrome virus infection.