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Drug used to treat Helicobacter pylori infection reduces SARS-CoV-2 viral loads in lungs and alleviates virus-associated pneumonia in a golden Syrian hamster model.
Very-long-chain fatty acids (VLCFAs) mediate recruitment of septins to the plasma membrane in fungal appressoria, leading to formation of a septin ring at the point of plant infection. VLCFA biosynthesis-inhibiting chemicals prevent septin assembly and have broad-spectrum fungicidal activity.
Spermine facilitates mucilage production and rice cell invasion by mitigating endoplasmic reticulum stress in the developing Magnaporthe oryzae appressorium.
Using single-particle analysis cryogenic electron microscopy, the authors determine the structures of the bacterial flagellum stator complexes from three diverse bacteria.
Cryo-electron microscopy structures of three varicella-zoster virus (VZV) capsids show VZV-specific features of the capsid-associated tegument complex (CATC) and genome packaging. The authors conclude that the VZV capsid is less stable and the CATC binds more weakly than in the homologues in other herpesviruses, characteristics that are linked to the small genome size of VZV.
Preclinical studies show that fluoxazolevir, which inhibits the fusion of hepatitis C virus (HCV) with hepatic cells by binding viral envelope protein 1, could be useful in drug cocktails to treat HCV.
Large freshwater phage genomes can encode the pmoC gene, an important subunit of the methane oxidation enzyme, methane monooxygenase. These genes are similar to bacterial homologues and are actively expressed in situ. Further work is needed to confirm whether these phages contribute to methane oxidation in the environment.
The authors do a CRISPR-knockout selection to investigate host factors required for influenza replication. They identified IFIT2 as being repurposed by influenza to promote replication.
Transcriptional and functional immune-cell profiling reveals that Candida auris is a strong inducer of innate host defence and identifies possible targets for adjuvant immunotherapy.
An analysis of more than 5,000 CBASS systems from 38,000 bacterial and archaeal genomes enabled a classification and nomenclature scheme to be devised for this growing field.
This study reports an improved poly(A)-independent single-cell RNA-sequencing protocol to capture growth-dependent gene expression patterns in individual Salmonella and Pseudomonas bacteria.
Outer membrane vesicles from Neisseria gonorrhoeae and other Gram-negative pathogens can kill macrophages via induction of mitochondrial apoptosis and activation of the pro-apoptotic BCL-2 family member BAK, and activate the NLRP3 inflammasome.
Dissimilatory sulfate reduction in archaeon ‘Candidatus Vulcanisaeta moutnovskia’ is distinct from bacterial sulfate reduction and sheds light on the evolution of sulfur metabolism.
This study describes the mechanism by which Chlamydia trachomatis reprogrammes host glutamine metabolism in a c-Myc-dependent manner. The authors show that glutamine uptake via the SLC15A transporter and glutaminolysis are crucial for peptidoglycan synthesis and Chlamydia replication.
In this manuscript, the authors address evolutionary questions on the emergence of SARS-CoV-2. They find that SARS-CoV-2 is not a recombinant of any sarbecoviruses detected to date, and that the bat and pangolin sequences most closely related to SARS-CoV-2 probably diverged several decades ago or possibly earlier from human SARS-CoV-2 samples.
This study reveals features of Epstein–Barr virus that are similar but not identical to the closely related Kaposi’s sarcoma-associated herpesvirus. The authors provide locations of protein components within the viral capsid and reveal different conformers of protein components by revealing variations in links between capsid proteins and exploiting approaches with relaxation of symmetry. The capsid-associated tegument complex is loaded on to the capsid with long-range asymmetry, relative to the location of the portal vertex (the site of genome entry and egress).