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Comprenhensive analysis of human antibody responses to SARS-CoV-2 variants and animal sarbecoviruses finds that Omicron escapes neutralization more readily than distantly related animal sarbecoviruses.
The closed chromosome of an Asgard archaeon, Candidatus Odinarchaeum yellowstonii LCB_4, revealed CRISPR spacers, which were used to identify archaeal viruses.
The SARS-CoV-2 Lambda variant has been prevalent in Latin America. An analysis of the neutralization capacity of antibodies elicited by CoronaVac and BNT162b2 against SARS-CoV-2 Lambda in plasma from healthcare workers and patients in Chile reveals that BNT162b2 elicits higher neutralizing antibody titres than CoronaVac.
A third vaccination with BNT162b2 against SARS-CoV-2 elicits antibody and T-cell responses in 4 out of 5 reported older adults who were previously low-/non-responders.
The marine bacterium Puniceibacterium antarcticum SM1211 can produce acrylate from dimethylsulfoniopropionate (DMSP) cleavage by the DMSP lyase, DddL, which protects against grazing by a ciliate predator.
The authors characterize two phages against Acinetobacter baumannii, both in vitro and in vivo. A. baumannii strains develop resistance against both phages, but are in turn resensitized to different antimicrobial compounds.
BiofilmQ is an image cytometry software tool that enables the visualization, quantification and analysis of biofilm properties, providing insights into their structure and function.
Electron micrographs show that mouse and rat segmented filamentous bacterium (SFB) unicellular intracellular offspring (IO) are flagellated and that flagellation occurs before IO release from SFB filaments.
Resistance to baloxavir marboxil, a recently approved drug to treat influenza infection, was thought to make the virus less fit. This study reports that resistant viruses isolated from Japanese patients have normal replicative abilities and pathogenicity in animal models and thus might spread in humans.
A statistical analysis of the associations between virus structure and virus transmission suggests that virus structures limit viral transmission routes and have implications for infection prophylaxis and gene therapy strategies.
A comparative transcriptional analysis identifies human HLA-DR as a factor that mediates entry of bat influenza A-like H17-pseudotyped viral particles into mammalian cells.
Idionectes vortex is a flagellated unicellular microbial eukaryote with a unique mode of motility; it resembles a doughnut-shaped object that swims by continuous inversion of its surface, similar to a vortex ring.
The authors report the development of a Madin-Darby canine kidney (MDCK) cell line that is more suitable than conventional MDCK or human virus receptor-overexpressing cells for the isolation and propagation of human influenza viruses without cell culture-adaptive mutations.
Adaptive laboratory evolution experiments in Escherichia coli show that the pseudogene efeU can be repaired to restore the bacterium’s iron uptake system, demonstrating that pseudogenes may serve as an ‘adaptive repertoire’ of selectable traits.
Genomic characterization of a new ebolavirus, detected in free-tailed bats in Sierra Leone, whose viral glycoprotein can mediate entry into human cells.
