Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
LILAC is a photoactivatable version of Lifeact, a tool for labeling F-actin. LILAC can help avoid cytotoxicity, which is sometimes associated with the use of Lifeact.
DeePiCt (deep picker in context) is a versatile, open-source deep-learning framework for supervised segmentation and localization of subcellular organelles and biomolecular complexes in cryo-electron tomography.
This work presents a computational framework, COMMOT, to spatially infer cell–cell communication from transcriptomics data based on a variant of optimal transport (OT).
An optimized pipeline for improved inference and analysis of structural variants (SVs) has been developed, which uses Iris for refining breakpoints and sequences, and Jasmine for comparing SV calls at population scale.
A computational pipeline for haplotype-aware pantranscriptome analysis has been developed, which enables spliced pangenome graph construction, RNA sequencing data alignment, and estimation of haplotype-specific transcript expression levels.
Cryogenic correlated light, ion and electron microscopy (cryo-CLIEM) integrates three-dimensional confocal microscopy with focused ion beam–scanning electron microscopy for efficient preparation of lamellae containing target structures for in situ structural biology with cryo-electron tomography.
The ELI-TriScope advances cryo-CLEM by focusing light, electron and ion beams on cryopreserved samples for markedly improved preparation of cryo-lamellae containing target structures.
The Photopick platform, which can be used for phenotype-activated cell selection, was used to develop the improved voltage sensors QuasAr6a and QuasAr6b. These GEVIs offer improved signals and are useful for all-optical electrophysiology.