News & Comment

De novo assembly of human genome sequences that are not currently included in the reference genome opens the possibility of a human pan-genome.

An in-depth, systems biology approach to analyzing a 'reduced genome' bacterium reveals startling complexity.

By sampling a two-dimensional diffraction pattern on a spherical detector, three-dimensional structure determination of single molecules should be possible from a single measurement.

The Negatome is a database of non-interacting protein pairs that can be used for training protein-protein interaction prediction algorithms.

Screening reveals a chemical activator that triggers apoptosis by locking inactive but dynamic proenzymes into a more active state, suggesting a promising strategy for targeting proteases.

A new technique finds genomic subpopulations to indicate cancer progression.

High-throughput saturation mutagenesis determines the contribution of each base in a core promoter to overall promoter strength.

A miniature head-mounted two-photon microscope small enough for a rat to carry allows researchers to visualize neuronal signaling while the animal freely interacts with its environment.