News & Comment

A panel of advanced methods reveals that retrotransposable elements are more prevalent than suspected in human genomes.

Visualization of newly synthesized proteomes using conventional fluorescence microscopy reveals the local nature of protein translation.

Nanoscale robots can be programmed to walk a DNA origami track.

Raw data of millions of sequences used to assemble the reference genomes of ten organisms are analyzed in search of mismatches indicative of editing events. Findings include candidate sites for in vivo DNA and RNA editing, and a common sequencing error.

A technique combining laser and electron pulses is used to achieve nanometer and femtosecond resolution in biological imaging.

Live-cell time-lapse imaging of somatic cells undergoing reprogramming raises interesting questions about the mechanism of the process.

New strategies expand the genetic toolkit for transgene expression, lineage tracing and mosaic analysis of gene function in flies and mammalian cells.

Researchers synthesized the first functional synthetic bacterial genome; repeating this feat with different bacteria will require further methodological development.

Applying technology developed for next-generation DNA sequencing to study translation, researchers watch individual ribosomes string together amino acids in real time.

Using a combination of methodologies, researchers map the genetic basis of complex traits in yeast.

Multiple photodiode detectors are used to track the transit of dye-labeled single lipids through an excitation spot at high resolution.

A new technique for transcriptome-wide isolation of RNAs bound to specific proteins reveals, with high resolution, the location of RNA-binding proteins on their target RNAs.

The Dynameomics database houses native-state and high-temperature unfolding simulation data for the 100 most populated protein folds; such information provides insights into protein function beyond structure alone.

High-throughput imaging of genome-wide RNA interference screens and systematic analysis of protein complexes involved in mitosis yield valuable resources and reveal new subunits of well-characterized complexes.

Monitoring the activity of neurons in vivo in the freely behaving zebrafish larvae is now possible using bioluminescence, an approach with great potential for unveiling how neuronal networks control behavior.

Whole-genome sequencing of DNA from two children with Mendelian disorders and from their healthy parents allows efficient correction of sequencing errors and the identification of causal genes.

A systematic map of pair-wise physical interactions among mammalian transcription factors will enable studies of transcriptional control in development and disease.