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The Dynameomics database houses native-state and high-temperature unfolding simulation data for the 100 most populated protein folds; such information provides insights into protein function beyond structure alone.
New genetic technologies in the rat open new research opportunities and call for more careful choice of the most suitable model organism before embarking on a study.
High-throughput imaging of genome-wide RNA interference screens and systematic analysis of protein complexes involved in mitosis yield valuable resources and reveal new subunits of well-characterized complexes.
Researchers try multiple means to get high-quality membrane proteins for X-ray crystallography and nuclear magnetic resonance (NMR) spectroscopy studies.
Monitoring the activity of neurons in vivo in the freely behaving zebrafish larvae is now possible using bioluminescence, an approach with great potential for unveiling how neuronal networks control behavior.
Whole-genome sequencing of DNA from two children with Mendelian disorders and from their healthy parents allows efficient correction of sequencing errors and the identification of causal genes.
A systematic map of pair-wise physical interactions among mammalian transcription factors will enable studies of transcriptional control in development and disease.