News & Comment

New software tools help take the pain out of working with huge three-dimensional image datasets and aid in mapping neuronal networks.

A study of the genetic variation in 17 human embryonic stem cell lines shows hundreds of changes, some associated with cancer.

Researchers evolved a ribosome that efficiently decodes quadruplet codons, thus opening up the possibility of genetically incorporating multiple unnatural amino acids into proteins.

Visualizing binding data in the form of specificity landscapes yields new insight into the behavior of DNA-binding molecules.

Researchers develop a method to label GlcNAc residues of N-glycans in yeast with high specificity and efficiency.

A creative application of protein labeling can probe uncharacterized genomes.

A new cell-based fluorescent reporter system allows direct visualization of individual cells infected with hepatitis C virus in real time.

A genome-wide map of nucleosome positions in Schizosaccharomyces pombe points to a positioning mechanism different from that of other organisms.

A new study, pooling brain-imaging data from 35 centers across the world, shows the power of data sharing and demonstrates a universal architecture of functional connections in the human brain.

Researchers map functional interactions for 75% of the yeast genome using synthetic genetic array methodology.

Mice with inducible reporter genes allow systemic profiling of gene expression throughout the brain.

Researchers engineer biological 'nanofactories' that can trigger a quorum sensing response in bacteria.

Addition of next-generation sequencing to an assay of replication timing enables high-resolution genome-scale analyses of multiple cell types.

A method to differentially label each sister chromatid in a cell makes it possible to elucidate segregation patterns after mitosis and should help to pinpoint the mechanism behind nonrandom segregation in certain cell types.

The pioneers of the first generation of widely used optogenetic tools now describe new variants that open further possibilities for studying neural function.

Subtle modifications to a red fluorescent protein make it highly effective for intravital imaging.

Annotation of clinical databases using controlled vocabulary permits cross-species comparisons of phenotypes associated with human disease.

Two GFP-binding peptides, Enhancer and Minimizer, modulate GFP fluorescence and will enable a number of in vivo applications.