A method to differentially label each sister chromatid in a cell makes it possible to elucidate segregation patterns after mitosis and should help to pinpoint the mechanism behind nonrandom segregation in certain cell types.
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References
Falconer, E. et al. Identification of sister chromatids by DNA template strand sequences. Nature 463, 93–97 (2010).
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Rusk, N. Immortal strands versus silent sisters. Nat Methods 7, 174–175 (2010). https://doi.org/10.1038/nmeth0310-174a
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DOI: https://doi.org/10.1038/nmeth0310-174a