Research Highlights

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  • Photonic resonator interferometric scattering microscopy offers label-free imaging of biomolecules in vitro with improved signal-to-noise ratio.

    • Rita Strack
    Research Highlight
  • The split-pool barcoding strategy has been extended to single-cell RNA sequencing (scRNA-seq) of microbes.

    • Lei Tang
    Research Highlight
  • KIN-CLIP allows determination of binding and dissociation kinetics of RNA-binding proteins in cells.

    • Arunima Singh
    Research Highlight
  • In situ long-read sequencing combined with expansion microscopy enables precise views of transcriptomes in intact biological systems.

    • Rita Strack
    Research Highlight
  • Researchers report a method to generate two-component protein arrays on living cells, which enables controlled receptor clustering.

    • Lei Tang
    Research Highlight
  • TopoBuilder enables de novo design of proteins bearing complex structural motifs.

    • Arunima Singh
    Research Highlight
  • Human tonsil organoids recapitulate key features of the antigen-specific B cell response.

    • Madhura Mukhopadhyay
    Research Highlight
  • Global protein structure readouts help detect protein functional changes.

    • Arunima Singh
    Research Highlight
  • DeepLabCut-Live! performs pose estimation in real time and allows closed-loop feedback on behavior.

    • Nina Vogt
    Research Highlight
  • Loop-seq is a high-throughput sequencing assay that measures DNA looping and can help explain how DNA bendability contributes to nucleosome organization.

    • Lei Tang
    Research Highlight
  • DNA-PAINT with left-handed DNA oligomers enables imaging of nuclear structures with reduced background.

    • Rita Strack
    Research Highlight
  • Assembloids recapitulate organ spatial organization and interaction with high fidelity.

    • Madhura Mukhopadhyay
    Research Highlight