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A sequencing approach, m6A-LAIC-seq, globally quantifies the proportion of m6A-modified transcripts of a specific gene and the differential m6A modification levels among its isoforms.
Two new approaches for target profiling of RNA-binding proteins require less cell material, avoid radioactive reagents and give more accurate data in a shorter time compared to previous methods.
To drive its migration through a fibrillar matrix—and thus to spread, invade or metastasize—a cancer cell must exert physical forces. The first visualization of these forces in three dimensions reveals surprising migration dynamics.