Method to Watch

Large language models are learning the language of genomics.

Developments in nanopore-based peptide detection and sequencing show promise of a breakthrough.

Spatially resolved multimodal omics offers a collective way to capture molecular information in complex tissues.

High-resolution connectomics of the human brain is the next frontier in neuroscience.

New twists on established methods and multimodal imaging are poised to bridge gaps between cellular and organismal imaging.

Advances will enable proteome-scale structure determination in cells.

Artificial ECMs enable recapitulation of tissue microenvironments.

Advances in profiling chromosome structure help reveal the regulatory roles of gene organization.

Mechanoimmunology methods help dissect the mechanical forces within the immune system.

CRISPR systems can be leveraged to direct recombinases to integrate gene-sized DNA sequences.

Strategies to overcome poor reproducibility in MRI studies are needed.

In vitro models and single-cell atlases help uncover the mysteries of human embryogenesis.

Computational approaches are pushing the limits of unknown metabolite annotation.

Advances in fluorescence microscopy and spectroscopy show their promise for applications that complement in situ structural biology methods like cryoelectron tomography.

The combination of microscopy, targeted illumination and single-cell sequencing is driving applications from direct evolution to spatial omics.

Data integration methods weave genomics data into holistic pictures of biological systems.

Lineage tracing methods help unravel complexities of cell state and differentiation programs.

Viral tools are a mainstay in mammalian neuroscience, but there is room for improvement.

Advances in label-free microscopy are expanding experimental observations, from biophysics to cell biology and beyond.

The diverse microbial world provides unprecedented potential for exploring genome editing tools.