Technology Features

Genome assembly projects get a boost from high-accuracy long-read sequencing.

Nature Methods has crowned spatially resolved transcriptomics Method of the Year 2020.

CRISPR, now a Nobel-Prize-winning technology, comes in many flavors. And so do gRNAs.

Algorithms trained to interpret microscope data can greatly extend the information that can be derived from the resulting images, or even optimize how imaging experiments are conducted.

To better study human neurodevelopment, researchers advance organoids as brain models.

With advanced approaches to sample preparation and data analysis, scientists doing cryo-EM are starting to infer molecular movements from samples that are, literally, frozen.

There’s a growing affinity for recombinant antibodies. Some say it’s also high time for animal-free recombinants.

‘Omics pipeline builders and users face options and tough decisions.

Phase separation creates complex condensates in eukaryotic cells. To study these mysterious droplets, many disciplines come together.

To thwart SARS-CoV-2, labs hurry to hone assays, swap findings and share resources.

T cells race to the scene in cancer and infection. To tease out what is special in cancer, scientists widen their scope and tool sets.

Some -omics tools can be more accurate, sensitive or efficient than others. Yet benchmarking is no tell-all.

Microbiologists stake their claim: assessing climate change involves new ways of studying the ocean’s microbes.

Change is a constant in the burgeoning field of metabolomics. That includes data analysis tools and repositories.

Label-free imaging lets labs ‘see’ their samples less invasively than other techniques.

Mechanical measurements would be easy if cells were homogeneous objects — they’re not.

Labs in different neuropsychiatry subfields don’t always see eye to eye, but convergent approaches help them join forces to study these difficult conditions.

As single-cell proteomics emerges, perhaps labs can avoid the need to infer protein levels from mRNA abundances.

Nanopore sequencing’s early adopters are pushing the limits of what can be achieved with ultra-long DNA reads, and they are also finding innovative ways to apply this technology to other biological questions.

The gut, plant roots, ocean sediments: microbiome engineers travel to explore and model microbially complex systems.