Research Highlights

Researchers exploit crystal imperfections to solve protein structures at resolutions beyond the X-ray diffraction limit.

Researchers have developed a set of fluorescent-protein-based sensors for endogenous nitric oxide.

Genetic background trumps tissue of origin as a source of variability between induced pluripotent stem cell lines, diminishing the role of somatic memory in reprogrammed cells.

Synthetic Notch receptors with chimeric extra- and intracellular domains can be tailored to tune cell-cell communication.

A microfluidic device tracks the lineage and transcriptional profiles of individual cells.

Scientists can maintain orthogonal translation systems over many bacterial generations by making an essential gene depend on a nonstandard amino acid.

A nanopore built from DNA allows the controlled and selective transport of organic molecules across a lipid membrane.

The use of photoswitchable fluorescent proteins in STED nanoscopy enables higher-contrast imaging with dramatically reduced photobleaching.

An unsupervised approach with high predictive power provides a single measure of functional importance for each variant in the human genome.

A combination of flexible imaging and computational methods opens new views into the dynamics of activity across large populations of neurons.

Researchers monitor cotranslational protein folding in real time.

Absolute levels of the Escherichia coli proteome measured under 22 different conditions represent a valuable resource.

Patch-seq integrates functional and molecular properties of single neurons to tackle heterogeneity in the brain.

Laboratory tests show that gene drives could obliterate wild mosquito populations carrying the malaria parasite, or make them resistant to its transmission.

Small chemical tweaks during tissue preparation make a big difference for imaging thick, complex biological samples.

Increasing the sensitivity of DNase-seq allows chromatin accessibility to be profiled from very low numbers of cells.

Cells are under mechanical tension in their native environment. New genetically encoded tension sensors can make a broader range of these forces visible.

Engineered Jedi T cells scour the body to eliminate GFP-expressing cells.

A map of mammalian protein interactions highlights the importance of substoichiometric interactions.

Ultrafast ultrasound microscopy allows for super-resolution ultrasound imaging of vasculature in whole organs.