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    Nature Methods is taking part in Guided Open Access (OA), a pilot designed to make the process of publishing open access simpler, quicker, and more efficient. In Guided OA, an article is considered collaboratively at a group of associated journals, and authors are then guided through the process to find the best home for their work.

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    Machine learning-based approaches are being increasingly applied in life sciences research. This series of articles proposes community reporting standards, intended to help improve the reproducibility and usability of machine learning-based analyses.

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  • Researchers identified a single-effector Cas, Cas7-11, that architecturally diverges from previous CRISPR single- or multi-component systems and can possess RNA knockdown activity without detectable collateral activity in mammalian cells.

    • Lei Tang
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  • This month, we celebrate the value and beauty of images of biological processes captured by microscopes.

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  • An artificial system models the mechanical properties of the tumor microenvironment in vitro.

    • Madhura Mukhopadhyay
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  • Directed evolution of adeno-associated virus capsids with the DELIVER approach generates tissue-specific viruses.

    • Nina Vogt
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  • Four independent research groups have used proximity ligation techniques to profile the in vivo mouse secretome.

    • Rita Strack
    Research Highlight
  • The proliferation of versatile open software and hardware for microscopy is helping to democratize biological imaging for both current and aspiring scientists.

    • Michael Eisenstein
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