Read the May issue:
Focus on methods for immunology
Focus on methods for immunology
Spatial transcriptomics and mRNA splicing measurements encode rich spatiotemporal information for cell states and their transitions. We present a multiscale dynamical system method for reconstructing cell-state-specific dynamics and spatial state transitions. This theory-based approach reconciles short-timescale local tensor streamlines between cells with long-timescale transition paths that connect cell attractors.