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This Comment describes some of the common pitfalls encountered in deriving and validating predictive statistical models from high-dimensional data. It offers a fresh perspective on some key statistical issues, providing some guidelines to avoid pitfalls, and to help unfamiliar readers better assess the reliability and significance of their results.
Emily Mayhew, a historian within the Department of Bioengineering at Imperial College London, talks to Nature Materials about the advances that have been made in medicine and, in particular, prosthetics since World War I.
Prostheses today can trace their roots to the rudimentary designs of the First World War, but since then there have been significant advances that have improved the quality of life of amputees.
Space missions require materials that can preserve functional integrity under extreme conditions of heat, impact and radiation. This Comment outlines the materials properties needed for some of the most ambitious space missions and presents the design and testing principles before their incorporation.
Treating living matter as a material has immense biomedical potential, but it’s worth acknowledging how the notion unsettles longstanding preconceptions and raises challenging new questions.
Lessons learnt from Horizon 2020 and a determination to become a world-class hub for entrepreneurship form the basis of the European Commission’s ambitious Research and Innovation budget.
Large-scale, environmentally friendly hydrogen production will rely on steam methane reforming coupled with carbon capture and electrolysis, but solar fuels could have a disruptive role to play.
Camille M. Le Gall, Jorieke Weiden, Loek J. Eggermont and Carl G. Figdor provide an overview of immunotherapeutics for cancer treatment that harness dendritic cells, their challenges in clinical use, and approaches employed to enhance their recruitment and activation to promote effective anti-tumour immunity.
Darrell Irvine provides an overview of the recent advances in materials science that have enabled the use of innovative natural and synthetic compounds in vaccine development capable of regulating the potency and safety of new vaccines progressing towards the clinic.
Tumour heterogeneity and off-target toxicity are current challenges of cancer immunotherapy. Karine Dzhandzhugazyan, Per Guldberg and Alexei Kirkin discuss how epigenetic induction of tumour antigens in antigen-presenting cells may form the basis for multi-target therapies.
As the interaction of the immune system with the tumour microenvironment becomes increasingly understood, more evidence indicates how immunotherapy can be employed to better eliminate cancers.
Solar cells based on metal halide perovskites continue to approach their theoretical performance limits thanks to worldwide research efforts. Mastering the materials properties and addressing stability may allow this technology to bring profound transformations to the electric power generation industry.
