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Volume 27 Issue 1, January 2021

Volume 27 Issue 1

COVID-19 projections in the US

The study by Simon Hay and colleagues at the IHME COVID-19 Forecasting Team employs statistical and mathematical modeling to build projections of future courses of the COVID-19 pandemic in the USA under various scenarios of social-distancing measures and universal mask use, as represented in the cover image.

See Hay and colleagues

Image credit: Getty images. Cover design: Marina Spence.


  • Editorial |

    The United Nations Assembly has named 2021 the International Year of Peace and Trust. In that spirit, the world can look forward with hope to the international collaborations spearheaded by the World Health Organization and consider the challenges the agency has yet to face.

News Feature

  • News Feature |

    There has been a lot of hype around the applications of machine learning in medicine. But how is machine learning actually helping bench-to-bedside scientists and clinicians do their jobs?

    • Mike May


World View

  • World View |

    Stakeholders in public health must lobby policy makers to make decisions based on evidence, not political expediency, particularly when the studies that hang in the balance are critical to understanding the origins of epidemics.

    • Angela L. Rasmussen



  • Q&A |

    The pandemic has thrust many mainstream journalists into unfamiliar grounds, including coverage of expert opinion that is not backed up by peer-reviewed content, reporting on preprints, and assessing high-complexity instant-response science. How did they manage? We asked five journalists from mainstream media about their experience.

    • Anita Makri

Research Highlights

News & Views

  • News & Views |

    An algorithm developed through machine learning on existing radiological data from diverse people has the potential to improve the diagnosis and management of knee pain from osteoarthritis and reduce racial disparities in the assessment of knee pain.

    • Said A. Ibrahim
  • News & Views |

    Analysis of glycemic and non-glycemic characteristics in individuals at risk for type 2 diabetes identifies six putative subgroups that differ in terms of risk of diabetes progression and complications.

    • Miriam S. Udler
  • News & Views |

    Liver metastases lead to resistance to immunotherapy through the ‘siphoning’ of tumor antigen–specific CD8+ T cells into the liver, which results in a systemic ‘immune desert’ incapable of controlling tumor burden.

    • Katherine E. Lindblad
    •  & Amaia Lujambio


Review Articles

  • Review Article |

    Increased understanding of the biology of metastases allows improved targeting and outcomes for patients with both micro- and macrometastases.

    • Karuna Ganesh
    •  & Joan Massagué

Brief Communications

  • Brief Communication |

    A comprehensive census of the dynamics of death and regeneration of cells and tissues provides an estimation of the distribution of cellular turnover in the human body.

    • Ron Sender
    •  & Ron Milo




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