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Volume 25 Issue 10, October 2019

Volume 25 Issue 10

TRACERx Lung: intratumor heterogeneity and clinical outcomes

Lung cancer is the leading cause of cancer-related deaths worldwide, with a five-year relative survival rate of 4% in the metastatic setting. In this issue, three reports from the TRACERx (TRAcking Cancer Evolution through therapy (Rx)) lung study provide insights into tumor evolution and intratumor heterogeneity that may facilitate the development of biomarkers and improve therapeutic outcomes for patients.

See: Dive and colleagues, Swanton and colleagues and Chain and colleagues.

Image credit: Jeroen Claus. Cover design: Erin Dewalt

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    Nature Medicine is taking a comprehensive approach for reporting clinical studies with the aim to increase transparency, promote rigorous reporting standards and engage with the community to meet the challenges of contemporary medicine.

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    Patrícia Brasil is head of the Laboratory of Acute Febrile Illness of the National Institute of Infectious Diseases Evandro Chagas, Fiocruz, and professor of tropical medicine and clinical research in the postgraduate programs of Fiocruz in Rio de Janeiro, Brazil.

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    Antibodies elicited by the widely deployed rVSV-EBOV Ebola virus vaccine mirror those of disease survivors, animal models and other vaccine platforms. Notably, neutralizing antibodies are consistently elicited from a recurring pair of germline genes.

    • Erica Ollmann Saphire
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    A novel oral capsule can deploy microneedle patches that release drugs into the intestinal wall for uptake into the bloodstream as shown in animal studies, thereby avoiding injections.

    • Mark R. Prausnitz
    • Yasmine Gomaa
    • Wei Li
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    An engineered truncated gene derived from the dystrophin-related protein (utrophin), prevents pathology without an immune response in an animal model of Duchenne muscular dystrophy (DMD) gene therapy.

    • Kay E. Davies
    • Jeffrey S. Chamberlain
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    Single-cell RNA sequencing characterizes clonal dynamics and distinct cellular states contributing to intratumoral heterogeneity in glioblastoma and medulloblastoma.

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