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Volume 21 Issue 8, August 2015

Volume 21 Issue 8

Two papers in this issue reveal new insight into lung regeneration. Rosen et al. (p 869) report that preconditioning by sublethal radiation allows better engraftment of embryonic lung tissue into the injured lung of adult mice, leading to improved lung repair. Liu et al. (p 866) find by lineage tracing that c-kit+ cells do not, as previously reported, contribute to lung epithelium during homeostasis or repair after injury, but rather maintain an endothelial fate. Image shows a colored scanning electron micrograph of normal lung tissue, including the lumen of a blood vessel (yellow) lined with endothelial cells, as well as alveoli air sacs lined with capillaries (blue and pink). Image credit: Professor Pietro M. Motta / Science Source.

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  • News & Views |

    Rheumatoid arthritis (RA) is a debilitating autoimmune disorder, the etiology of which is poorly understood. A new study reveals dysbiosis in gut and oral microbiomes of affected individuals, potentially providing a basis for patient stratification and clues to pathophysiological mechanisms of RA onset and progression.

    • Geraint B Rogers
  • News & Views |

    A new study shows that astrocytes are involved in the development of chronic itch in a mouse model. This is dependent on upregulation of lipocalin 2 (LCN2) by the transcription factor STAT-3 and astrogliosis.

    • Dustin Green
    • Xinzhong Dong
  • News & Views |

    Engraftment of progenitor cells to effect repair of injured lungs has been a major challenge. A new study combines a conditioning strategy adopted from bone marrow transplantation with a lung injury model to bring this potential therapeutic approach closer to reality.

    • Hans-Willem Snoeck
  • News & Views |

    Aging is a major risk factor for cognitive decline and neurodegenerative diseases. A new study identified β2-microglobulin as a blood-borne factor that detrimentally influences the brain during the aging process.

    • Anthony J Filiano
    • Jonathan Kipnis


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