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Volume 21 Issue 7, July 2015

Volume 21 Issue 7

In this issue, we are proud to feature a collection of articles on inflammatory disease (pp 669–740). The cover image depicts the epithelium that lines the mouse gastrointestinal tract and influences immunity. The cell membrane of small intestinal epithelial cells is visualized in green with the nuclei shown in orange. Paneth cell granules at the base of the crypts are marked in blue. Image courtesy of Mario Noti, Gregory F. Sonnenberg and David Artis. Artwork by Erin Dewalt.


News & Views

  • News & Views |

    Two new studies demonstrate that so-called 'liquid biopsies' may reveal important genomic information needed to monitor treatment responses, forecast tumor recurrences, and provide a rationale for novel therapeutic strategies in patients with lung cancer and colon cancer.

    • Catherine B Meador
    •  & Christine M Lovly
  • News & Views |

    Muscle fibrosis after acute injury can be debilitating, but in chronic muscle disease it can be lethal. A new study reveals that shifts in macrophage phenotype in injured or diseased muscle can influence whether connective tissue production by fibro/adipogenic precursors in muscle is beneficial or pathological.

    • James G Tidball
    •  & Michelle Wehling-Henricks
  • News & Views |

    Adipocyte progenitors have the capacity to differentiate into mature brown adipocytes with thermogenic capabilities. Two new studies identify novel markers to help prospectively isolate these and mature adipocytes from human brown fat biopsies.

    • Mariëtte R Boon
    • , Emmani B M Nascimento
    •  & Wouter D van Marken Lichtenbelt


  • Editorial |

    Inflammatory disease research is burgeoning. Large data sets are being generated to characterize the human immune response, while detailed mechanistic studies are defining the role of specific cell types and sensors in inflammatory disease. Future efforts are needed to integrate these approaches and guide precision medicine.


  • News |

    As it becomes evident that the microbiome exerts an influence on the human immune system, scientists have begun to ponder therapies that might act on intestinal microbes to reduce harmful inflammation. Roxanne Khamsi reports.

    • Roxanne Khamsi

Review Article





  • Focus |

    Inflammatory Disease

    There is an emerging understanding of how the disruption of immune homeostasis may lead to the development of chronic inflammatory diseases. This series of articles highlights new data that point toward the influence of environmental factors and addresses recent advances in our knowledge of the cell types and signaling pathways involved in inflammatory disease onset and progression.


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