Reviews & Analysis

As polygenic risk scores move closer to widespread clinical use, this Perspective summarizes the benefits, risks and challenges to be overcome.

In this Perspective, the authors discuss the ethical challenges of individualized therapy (also called n-of-1) trials and argue that, although customized for the patient, these constitute ‘research’ nonetheless.

This Perspective discusses recent developments in NSCLC immunotherapy and targeted therapy, and highlights the key challenges and future directions for NSCLC management.

Microbiome science is fast advancing and its careful integration into public health is detailed in this Perspective.

Global coordination of public health efforts will be needed to defeat the COVID-19 pandemic and to prepare for future public health emergencies.

All countries worldwide have signed up to the United Nations Sustainable Development Goals and committed to the objective of achieving universal health coverage. Getting there will require understanding how packages of essential health services can be developed in resource-constrained settings and how experts and the public can make decisions about which health services should be provided free of charge.

Recent advances in computational and laboratory sciences are helping researchers to address large-scale sustained emergencies, such as the COVID-19 pandemic, and constantly adapt to the emergence of new questions, data and findings in order to synthesize real-time evidence that will inform policy decisions.

A comprehensive strategy for the next steps to ensure vaccination of the global population against SARS-CoV-2 is now required, and key steps and challenges are detailed in this Perspective.

The severity of COVID-19 varies by sex and age, and is linked to comorbidities. Differences in immune reactions may go some way to explain this.