Reviews & Analysis

Models of estrogen receptor–positive breast cancer are used to explore the rationale for androgen receptor agonists as treatments for breast cancer.

People on low-fat, low-energy-density diets have lower ad libitum energy intake than that of those on high-fat, high-energy-density diets.

CRISPR-Cas gene editing enters the field of promising clinical approaches for mitigating hemoglobin defects in patients with hemoglobinopathies.

New personalized brain-stimulation methods for the treatment of depression and obsessive–compulsive symptoms provide hope for future treatment applications.

An algorithm developed through machine learning on existing radiological data from diverse people has the potential to improve the diagnosis and management of knee pain from osteoarthritis and reduce racial disparities in the assessment of knee pain.

Analysis of glycemic and non-glycemic characteristics in individuals at risk for type 2 diabetes identifies six putative subgroups that differ in terms of risk of diabetes progression and complications.

Liver metastases lead to resistance to immunotherapy through the ‘siphoning’ of tumor antigen–specific CD8⁺ T cells into the liver, which results in a systemic ‘immune desert’ incapable of controlling tumor burden.