Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Machine learning can use patients’ demographic information and previous clinical history to help physicians select the antibiotics most likely to successfully treat urinary tract infections, despite growing levels of resistance.
Quorum-sensing bacteria can deliver a nanobody targeting the ‘don’t eat me’ ligand CD47 to tumors that results in systemic anti-tumor immunity-induced regression in mice.
The prevalence of excess weight gain is increasing more rapidly in rural than in urban environments. Increased intake of ultra-processed foods has been associated with obesity, and the rise of supermarkets and marketing strategies may have contributed to the greater weight increases in rural areas.
The combination of BRAF and MEK inhibition and anti-PD-1 is tolerable and has promising efficacy, which warrants further investigation into its use as melanoma therapy.
Assessment of more than 400,000 people over the age of 40 demonstrates that homozygosity for a CCR5 variant that prevents HIV-1 infection comes at the cost of increased rates of mortality.
Multi-omics longitudinal profiling of individuals can detect subtle changes in health status at the earliest possible time point, allowing preemptive initiation of mechanism-appropriate disease-prevention strategies.
Human survivors of Ebola virus disease are more likely than uninfected controls to develop memory loss, uveitis, and other abnormal conditions, and Ebola virus remains in semen much longer than previously thought.
Three innovative precision medicine studies show the utility of evidence beyond that from tumor DNA sequencing to guide therapy in patients with cancer.
A new drug restores a compromised intestinal barrier and ameliorates colitis in mice by modulating paracellular permeability through a newly discovered mechanism.
A large study provides causal evidence of the opposing effects of plasma low-density lipoprotein (LDL) levels on ischemic and hemorrhagic stroke in a Chinese population and suggests there is a a net benefit associated with LDL lowering.
Improved protocols for the visualization of immature neurons in the human brain provide evidence for generation of neurons in the adult hippocampus and uncover reduced neurogenesis in Alzheimer’s disease.
Application of immunoprofiling of human peripheral blood samples from an aging cohort identifies changes in the immune system that inform our understanding of age-associated complex diseases.
Transcriptional signatures and immune cell infiltrates associated with immune activation distinguish patients with glioblastoma who initially respond to immune checkpoint blockade from those who do not.
Non-invasive prenatal diagnostics allow for the successful identification of paternally inherited and de novo mongenic diseases using circulating cell-free DNA.
The analysis of autopsy material from individuals with multiple sclerosis with single-cell transcriptomics and 14C carbon dating calls for a reevaluation of mature oligodendrocytes in myelin repair.
Two new biomarkers for Alzheimer’s disease include one in the blood that relates to neurodegeneration and another that reflects blood–brain barrier dysfunction and is identifiable in cerebrospinal fluid analysis.
Counteracting splice defects in the CEP290 gene using RNA antisense oligonucleotides or Cas9-mediated gene editing is a therapeutic strategy for Leber congenital amaurosis type 10—a severe untreatable retinal dystrophy leading to childhood blindness.
