Atherosclerosis is the primary cause of heart attacks and strokes and is caused by a chronic inflammatory response in the coronary and carotid arteries. A new study shows that smooth muscle cells within atherosclerotic plaques can change phenotypes to become macrophage-like cells, thereby revealing the remarkable plasticity of these cells.
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References
Moore, K.J. & Tabas, I. Cell 145, 341–355 (2011).
Robbins, C.S. et al. Nat. Med. 19, 1166–1172 (2013).
Feil, S. et al. Circ. Res. 115, 662–667 (2014).
Shankman, L.S. et al. Nat. Med. 21, 628–637 (2015).
Breyer, A. et al. Exp. Hematol. 34, 1596–1601 (2006).
Rong, J.X., Shapiro, M., Trogan, E. & Fisher, E.A. Proc. Natl. Acad. Sci. USA 100, 13531–13536 (2003).
Gomez, D., Shankman, L.S., Nguyen, A.T. & Owens, G.K. Nat. Methods 10, 171–177 (2013).
Yoshida, T., Kaestner, K.H. & Owens, G.K. Circ. Res. 102, 1548–1557 (2008).
McConnell, B.B. & Yang, V.W. Physiol. Rev. 90, 1337–1381 (2010).
Sharma, N. et al. Arterioscler. Thromb. Vasc. Biol. 32, 2836–2838 (2012).
Zhou, G. et al. J. Clin. Invest. 122, 4727–4731 (2012).
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Rosenfeld, M. Converting smooth muscle cells to macrophage-like cells with KLF4 in atherosclerotic plaques. Nat Med 21, 549–551 (2015). https://doi.org/10.1038/nm.3875
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DOI: https://doi.org/10.1038/nm.3875
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