Spontaneous calcium release from intracellular stores can trigger irregular heart beats and sudden death. A new study shows that the heart failure drug carvedilol prevents irregular heart beats by a unique action on calcium release channels (pages 1003–1009).
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Zheng, Z.J., Croft, J.B., Giles, W.H. & Mensah, G.A. Circulation 104, 2158–2163 (2001).
The Cardiac Arrhythmia Suppression Trial (CAST) Investigators. N. Engl. J. Med. 321, 406–412 (1989).
Waldo, A.L. et al. Lancet 348, 7–12 (1996).
Moss, A.J. et al. N. Engl. J. Med. 346, 877–883 (2002).
Zhou, Q. et al. Nat. Med. 17, 1003–1009 (2011).
Mochizuki, M. et al. J. Am. Coll. Cardiol. 49, 1722–1732 (2007).
Reiken, S. et al. Circulation 107, 2459–2466 (2003).
Guo, T. et al. Circ. Res. 106, 1743–1752 (2010).
Lehnart, S.E. et al. J. Clin. Invest. 118, 2230–2245 (2008).
Hilliard, F.A. et al. J. Mol. Cell. Cardiol. 48, 293–301 (2010).
Watanabe, H. et al. Nat. Med. 15, 380–383 (2009).
Hwang, H.S. et al. Circ. Arrhythm. Electrophysiol. 4, 128–135 (2011).
van der Werf, C. et al. J. Am. Coll. Cardiol. 57, 2244–2254 (2011).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Knollmann, B. Carvedilol tweaks calcium release to ease arrhythmias. Nat Med 17, 923–924 (2011). https://doi.org/10.1038/nm.2441
Published:
Issue Date:
DOI: https://doi.org/10.1038/nm.2441
This article is cited by
-
Calsequestrin Mutations and Catecholaminergic Polymorphic Ventricular Tachycardia
Pediatric Cardiology (2012)