Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Toren Finkel reviews how metabolism and aging are connected, and highlights pathways that could be pharmacologically targeted to combat aging and age-related disease.
In this Review, Jan van Deursen and his colleagues discuss the recent progress in understanding the origin and identity of senescent cells in ageing and their contribution to age-related disease, in addition to discussing the potential for targeting these cells to counteract disease.
Maite Huarte discusses our current understanding of the impact of long noncoding RNAs on tumor growth and progression, and how this knowledge might be translated into new therapeutic approaches.
Recent studies have provided insight into how the environment, and in particular the diet, influence the development of lymphocytes. Emerging studies indicate a role for this immune development in inflammatory disease.
Tissue-resident memory T cells are increasingly being linked to human tissue-specific immune and inflammatory disease. These roles are discussed in this review.
Cua and colleagues discuss the cellular and molecular rationale for targeting IL-12 and IL-23 for therapeutic purposes in inflammatory diseases; they also review existing clinical data, discuss potential side effects, and propose future directions for targeting these cytokines in additional disorders.
Recent advances in genetics have deepened our understanding of the pathogenic mechanisms behind autoimmune and immune-mediated diseases. This has revealed both shared pathways and a considerable degree of heterogeneity between diseases.
The progress in understanding the mechanistic causes of anemias such as hemoglobinopathies and rare genetic disorders, as well as advances in therapies for anemias are reviewed.