Research Highlights in 2024

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  • Researchers have developed a low-resource, environmentally friendly cancer-diagnosis platform that detects metabolites in dried serum spots.

    • Karen O’Leary
    Research Highlight
  • A randomized controlled trial involving a telemedicine-based approach for the management of patients with acute coronary syndrome had several clinical benefits relative to standard of care.

    • Sonia Muliyil
    Research Highlight
  • An mRNA-based drug aims to replace a faulty enzyme and restore metabolic function in children with propionic acidemia — with encouraging early clinical results.

    • Karen O’Leary
    Research Highlight
  • In a multicenter clinical trial, patients with early-stage Parkinson’s disease treated with lixisenatide, a drug currently used for the treatment of diabetes, showed improvement in their motor scores compared with those on placebo.

    • Sonia Muliyil
    Research Highlight
  • Researchers developed an AI model that designs novel, synthesizable antibiotic compounds — several of which showed potent in vitro activity against priority pathogens.

    • Karen O’Leary
    Research Highlight
  • Global nephrology societies have called on the WHO and health communities to tackle the growing burden of chronic kidney disease, which has been under-recognized for too long.

    • Karen O’Leary
    Research Highlight
  • Deployment of mobile vaccination teams to remote communities in Sierra Leone substantially increased COVID-19 vaccine uptake, and could potentially be bundled with other health interventions.

    • Karen O’Leary
    Research Highlight
  • Patients with carotid artery plaque that contain microplastics and nanoplastics were found to be at higher risk of cardiovascular events and mortality than those in whom the particles were not detected.

    • Sonia Muliyil
    Research Highlight
  • In rhesus macaques, treatment with an IL-15 superagonist and broad neutralizing antibodies led to durable suppression of viremia after discontinuation of antiretroviral therapy.

    • Karen O’Leary
    Research Highlight
  • MEGA is a new CRISPR-based RNA-editing platform with the ability to enhance the fitness of CAR T cells; it may also overcome certain limitations of conventional DNA-targeting CRISPR–Cas9 systems.

    • Karen O’Leary
    Research Highlight
  • In a head-to-head study, a multitarget version of the widely used FIT (fecal immunochemical test) showed a higher cancer detection rate than the standard test.

    • Karen O’Leary
    Research Highlight
  • An intervention that incorporates electronic pill boxes and remote adherence monitoring improved treatment success in patients with tuberculosis in Tibet — making this a promising strategy for low-resource settings.

    • Karen O’Leary
    Research Highlight
  • Neuroimaging data uncover dynamic trajectories associated with brain cortical changes in women during pregnancy and in the postpartum period that are influenced by the type of childbirth.

    • Sonia Muliyil
    Research Highlight
  • In patients with resected, high-risk melanoma, the addition of a personalized mRNA-based neoantigen therapy to adjuvant pembrolizumab was more effective than pembrolizumab alone.

    • Karen O’Leary
    Research Highlight
  • Implementation of multifactorial interventions in a low- to middle-income setting during preconception, pregnancy and early childhood resulted in improvements to child neurodevelopment at 24 months of age.

    • Sonia Muliyil
    Research Highlight