Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Identification and characterization of variants in HTR2C in people with severe obesity, reveals a role for serotonin 2C receptor in regulation of appetite, weight and behavior.
A genome-wide association study in large cohorts of patients with different types of cancer treated with immune checkpoint inhibitors identifies genetic variants associated with immune-related adverse events.
Genetic analyses in a cohort of patients with melanoma receiving immunotherapy reveal that variants in IL7 are associated with immune-related adverse events and highlight the role of B cells in mediating toxicity.
A prespecified analysis of the DELIVER clinical trial shows that the sodium/glucose cotransporter 2 inhibitor dapagliflozin benefits patients categorized as having heart failure with improved ejection fraction, a class of patients at high risk of cardiac events but for which limited treatment data are available.
Analyses of whole-genome sequencing data in children and validation in mouse models show that offspring born from blastocyst-stage embryo transfer have shorter leukocyte telomere lengths.
Using data from wearable activity monitors, this study shows that short bursts of physical activity that are done as part of daily life activities and that are only 1 or 2 minutes in length are associated with lower mortality, similar to the effects of regular exercise.
Transcriptomic analyses of acute phase whole blood from a large cohort of patients with COVID-19 identify molecular determinants of post-infection long-term sequelae.
In patients with metastatic triple-negative breast cancer, atezolizumab combined with immunogenic, anthracycline-based metronomic chemotherapy improves progression-free survival, including in patients with PD-L1negative disease.
A prespecified secondary endpoint from the TriMaster study demonstrates that after trying three different classes of diabetes medications most patients preferentially selected the drug that was associated with the best glycemic control on an individual level.
Using a randomized three-way crossover design and stratification approaches based on obesity and renal function in people with type 2 diabetes, the TriMaster study demonstrated that patients with obesity were more likely to have greater glycemic control with pioglitazone (a thiazolidinedione) than with sitagliptin (a DPP4 inhibitor) and that patients with eGFR 60–90 ml/min/1.73 m2 were more likely to achieve lower HbA1c levels on sitagliptin than on canagliflozin (an SGLT2 inhibitor).
Analysis of the results of a large clinical trial, EMPEROR-Preserved, shows that the SGLT2 inhibitor empagliflozin improves outcomes for heart failure patients with either mid-range (41–49%) or preserved (≥50%) ejection fraction, supporting the use of this drug for both categories of patients.
A CD8-specific, one-armed antibody positron emission tomography tracer enables the visualization of the immune response in patients with solid tumors before and after starting immunotherapy.
In a randomized control trial, individuals who received dietitian-led counseling in the supermarket, together with web-based tools, had improved dietary quality in comparison to a control group, as assessed by adherence to the heart-healthy DASH diet plan.
The mechanism of action of LNA043—a novel disease-modifying osteoarthritis treatment candidate—is characterized in preclinical studies and through transcriptomic profiling of cartilage from patients with osteoarthritis in a phase 1 trial.
Machine learning applied to electronic health records in two US cohorts from the RECOVER initiative identified four Long-COVID subphenotypes that differ in the involvement of organ systems, previous SARS-CoV-2 infection severity and underlying conditions.
Longitudinal study of plasma biomarkers, in two independent cohorts, highlighted only p-tau217 as a surrogate marker of disease progression in early Alzheimer’s disease, supporting the development of new disease-modifying treatments.
Cerebrospinal fluid measures of isoform-specific tau species from the microtubule-binding region serve as the first fluid biomarkers of primary tauopathy.
Carbon-containing particulates accumulate with age in a subset of macrophages in human lung-associated lymph nodes, decrease macrophage phagocytic capacity and turnover and disrupt lymphoid tissue structure, potentially compromising adaptive immune responses.
According to 2020 estimates from 185 countries, Asia and Africa have the most maternal orphans due to cancer, with breast and cervical cancers responsible for almost half of maternal cancers.
In this proof-of-concept prospective study, single-lead electrocardiograms obtained by smartwatches were able to identify individuals with left ventricular dysfunction, potentially serving as an early warning system for heart failure.