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The human coronary artery disease gene TCF21 promotes the transformation of smooth muscle cells within atherosclerotic plaques into a newly identified population of fibroblast-like cells that contribute to plaque stability.
A machine learning approach using high-dimensional phenotypic and functional profiling data identifies a multiple sclerosis-specific T cell population that is reduced following treatment.
On the basis of the personalized data of over 300,000 individuals with urinary tract infections, a machine-learning algorithm can help select an antibiotic for treatment of a urinary tract infection to which the infecting pathogen is not already resistant.
Zinc finger protein transcription factors are developed for the selective silencing of the mutant huntingtin gene in human neurons in vitro and multiple animal models of Huntington’s disease in vivo while preserving expression of the wild-type allele.
Bacteriotherapy using gut-derived bacteria from healthy human infants, but not infants with food allergies, suppresses food allergy symptoms in mice via induction of Foxp3 + Rorγt + regulatory T cells
Single-cell transcriptomics reveals immune and stromal compartment remodeling, including the enrichment of unique populations of epithelial cells and CD4+ T cells, in asthmatic lungs
Ancestry and socioeconomic factors influence predictable changes in the vaginal microbiome that occur early in pregnancy in women who experience normal term birth.
As part of the second phase of Human Microbiome Project, the Multi-Omic Microbiome Study: Pregnancy Initiative presents a community resource to help better understand how microbiome and host profiles change throughout pregnancy as well as to identify new opportunities for assessment of the risk of preterm birth.
The detrimental effects of aged blood on cognition and nervous system function in mice can be combatted by targeting brain endothelial cell dysfunction via inhibition of aberrant VCAM1 signaling at the blood–brain barrier.
A robust signature of circulating inflammatory proteins is causally associated with 10-year risk of progression to end-stage renal disease in diabetic patients
In situ vaccine recruits and activates cross-presenting dendritic cells and augments PD1 blockade efficacy in patients with indolent non-Hodgkin’s lymphoma.
Blockade of intrahepatic accumulation and function of platelets
represents a potential approach to treat non-alcoholic steatohepatitis (NASH) and
prevent subsequent progression to hepatocellular carcinoma
An integrated high-dimensional measurement of immune age describes a person’s immune status better than chronological age and predicts all-cause mortality.