Volume 6 Issue 6, June 2005

Volume 6 Issue 6

TCR engagement activates multiple signaling pathways. Weiss and colleagues (p 608) show optimal T cell activation requires recruitment of the kinase PAK1 to the immune synapse and is depicted here as a color gradient (blue through red). The original image (by Hyewon Phee) is a Z-stack composite of PAK1 fluorescence at the immune synapse; not shown is the antigen presenting cell. Artwork by Lewis Long.




  • Commentary |

    Lung mechanics, immunology, genetics, diet and endocrinology may act in a developmental context to link two complex traits: obesity and asthma.

    • Scott T Weiss

News and Views

  • News & Views |

    The MAP3K kinases are thought to mediate signaling 'downstream' of the Toll-like receptors. Analysis of the MAP3K ASK1 demonstrates additional complexity in Toll-like receptor signaling pathways involving reactive oxygen species.

    • Bing Su
  • News & Views |

    Cross-priming of cytotoxic T cells requires the transfer of antigens to dendritic cells from other cells. Careful analysis indicates that the antigens are peptides in association with chaperone proteins.

    • Cornelis J M Melief
  • News & Views |

    The function of CD14 in LPS signaling has remained enigmatic. Examination of the responses of cells and mice with defective CD14 shows that this molecule seems to modulate specific LPS recognition by TLR4.

    • Paul J Godowski
  • News & Views |

    Some microbes can circumvent phagocytosis by interfering with membrane transport systems. Brucella do this by making cyclic glucan molecules that interfere with lipid raft–mediated vacuole maturation.

    • Craig R Roy