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Epithelial cells of the gut are heavily glycosylated. Kiyono and colleagues review the evidence for the importance of this glycosylation to immunity, host–microbiome interactions and immunopathology.
In this Review, Chen and colleagues discuss recent advances in understanding of the cGAS–STING pathway, focusing on the regulatory mechanisms and roles of this pathway in heath and disease.
There is now a major effort to fully exploit the anti-tumor properties of NK cells in the clinic. In this Review, Smyth and colleagues detail recent advances in NK cell–based immunotherapies and discuss the advantages and limitations of these strategies.
IL-1α is a ubiquitously expressed cytokine that has diverse roles in immunity and homeostasis. Di Paolo and Shayakhmetov review IL-1α's distinctive and important role in inflammation.
Innate lymphoid cells (ILCs) arise from distinct hematopoietic progenitors. Zook & Kee discuss the transcriptional programs that direct the development of natural killer cells and various ILC subsets.
In this Review, Klose and Artis focus on how group 2 ILC and group 3 ILC responses are regulated and how they interact with other immune and non-immune cells to mediate their functions.
NK cells and ILC1s are developmentally distinct but share many functional similarities. Spits and colleagues describe current knowledge on the biology of these cells and the conditions under which they can be distinguished.
Whole-body metabolism can affect immune-cell function and vice versa. Turka and colleagues review the unique metabolic properties of Treg cells and how this relates to their function and the outcome of immune responses.
Control of infection depends on the efficient coordination of responses by various cell populations of the immune system. Gause and colleagues review the interactions between cells of the innate immune system and stroma that enable effective responses to invading pathogens.
IL-33 has well-described roles in type 2 immune responses; however, the scope of its functions are rapidly widening. Martin and Martin review the latest knowledge on IL-33 as an alarmin, intracellular molecule and cytokine.
