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The signaling pathways distinguishing positive and negative thymic selection are critical for establishing T cell immunity and tolerance. The kinase MINK might be an important component that differentiates these two events.
When confronted with a pathogen, the immune system must develop the appropriate type of immune response. Recent work provides new insight into how regulated gene activation and silencing occurs in helper T cells.
Human skin is surprisingly resistant to colonization by Escherichia coli, a prevalent commensal bacterium of the gut flora. An 11-kDa Zn2+-binding protein, psoriasin, is identified as the principal E. coli–bactericidal factor present at the surface of human skin.
