News & Comment

  • News & Views |

    The metabolic master regulator mTORC1 is shown to promote alternative macrophage activation via Semaphorin 6D reverse signaling and reprogramming of lipid metabolism.

    • Jayne Louise Wilson
    •  & Thomas Weichhart
  • News & Views |

    Analysis of whole-blood transcriptional profiles in adults hospitalized with influenza reveals time- and severity-related gene-expression signatures.

    • David F. Tough
  • News & Views |

    Naive T cells migrate rapidly through the lymph node. A high-resolution look at the chemokine receptor CCR7 and integrin LFA-1 reveals that T cells remain highly responsive to their microenvironment via instantaneous tuning of chemokine-regulated actin flow and integrin-regulated adhesion.

    • Patrick W. Oakes
    •  & Deborah J. Fowell
  • News & Views |

    Human affinity-matured antibodies to Klebsiella pneumoniae lipopolysaccharide O-antigen have different patterns of glycan fine specificity without being polyreactive. These antibodies might constitute an important mechanism for homeostatic control of the intestinal microbiome.

    • Jiwon Lee
    •  & George Georgiou
  • Meeting Report |

    Tuberculous meningitis is a serious, life-threatening disease affecting vulnerable populations, including HIV-infected individuals and young children. The US National Institutes of Health convened a workshop to identify knowledge gaps in the molecular and immunopathogenic mechanisms of tuberculous meningitis and to develop a roadmap for basic and translational research that could guide clinical studies.

    • Sanjay K. Jain
    • , David M. Tobin
    • , Elizabeth W. Tucker
    • , Vishwanath Venketaraman
    • , Alvaro A. Ordonez
    • , Lakshmi Jayashankar
    • , Omar K. Siddiqi
    • , Dima A. Hammoud
    • , Nemani V. Prasadarao
    • , Matyas Sandor
    • , Richard Hafner
    •  & Zsuzsanna Fabry
  • News & Views |

    The activating natural killer cell receptor NKG2C can specifically recognize peptides derived from the cytomegalovirus protein UL40 in the context of HLA-E. This drives the expansion of a population of adaptive NKG2C+ natural killer cells.

    • Carsten Watzl
  • News & Views |

    γδ T cells accumulate with age in adipose tissue and produce the cytokine IL-17, which controls the homeostasis of regulatory T cells and adaptive thermogenesis. Thus, maintenance of core body temperature unexpectedly relies on these adipose tissue–resident γδ17 T cells.

    • Pedro H. Papotto
    •  & Bruno Silva-Santos
  • News & Views |

    Myeloid cells exhibit different inflammatory phenotypes after brain injury, yet the relative mechanistic roles for these diverse cell types in post-traumatic tissue damage and repair remain controversial.

    • David J. Loane
    •  & Alan I. Faden
  • Comment |

    Mice are generally the ‘go-to’ organism for modeling of the human immune system, but this often leads to inaccurate interpretations. Ernst and Carvunis argue in this Comment that taking into account the evolutionary and environmental context can generate better models of disease.

    • Peter B. Ernst
    •  & Anne-Ruxandra Carvunis
  • News & Views |

    Evasion of the immune system and global activation of the immune system are hallmarks of human immunodeficiency virus (HIV) infection. Studies reveal that macrophages might be responsible for HIV-associated pathogenesis via resistance to killing and induction of chronic inflammation.

    • Peter Kelleher
    •  & Xiao-Ning Xu
  • News & Views |

    The role of the transcription factor c-Maf varies in different CD4+ T cell subsets and can be associated with either pro-inflammatory activity or anti-inflammatory activity, depending on the cell context.

    • W. Nicholas Haining
    •  & Sarah A. Weiss
  • News & Views |

    IL-33 is a mediator of allergic inflammation and is localized in mucosal tissues to respond rapidly to environmental insults. These include allergens themselves, which can directly activate IL-33 through their intrinsic proteolytic activity.

    • Dirk E. Smith