News & Comment

  • News & Views |

    Comprehensive mapping reveals that functional CD4+ and CD8+ T cells targeting multiple regions of SARS-CoV-2 are maintained in the resolution phase of both mild and severe COVID-19, and their magnitude correlates with the antibody response.

    • Leo Swadling
    •  & Mala K. Maini
  • News & Views |

    Costimulatory blockade via the CTLA-4–Ig fusion protein abatacept is beneficial in patients with early-onset type 1 diabetes, but some individuals benefit more than others. A new study reports that the pretreatment abundance of T follicular helper (TFH) cells could predict clinical responses to abatacept.

    • Estelle Bettelli
    •  & Daniel J. Campbell
  • News & Views |

    To trigger an adequate humoral immune response while ensuring self-tolerance, B cell activation is tightly controlled. A new study indicates that an NR4A-enforced built-in brake fine-tunes the early phase of transcriptional reprogramming induced by BCR stimulation.

    • Louisa Hill
    •  & Tanja A. Schwickert
  • News & Views |

    A vicious cycle, linking obesity with chronic inflammation, fuels the development and exacerbation of metabolic syndrome and other disorders. Modulation of mitochondrial energy metabolism via interleukin-1β signaling establishes a runaway positive-feedback loop that brings about and reinforces the sequelae of a high-fat diet.

    • Nektarios Tavernarakis
  • Meeting Report |

    “The role of cytokines in COVID-19” online symposium was presented on 18 June 2020 by the NIH/FDA Immunology and Cytokine Interest Groups and was purposed to discuss our rapidly changing understanding of COVID-19-related cytokine responses in different stages of infection, including the etiologies, downstream consequences and possible mitigation strategies. The recording is available at https://nci.rev.vbrick.com/sharevideo/03106730-66cc-47ba-870b-f6e6274a998a .

    • Maja Buszko
    • , Jung-Hyun Park
    • , Daniela Verthelyi
    • , Ranjan Sen
    • , Howard A. Young
    •  & Amy S. Rosenberg
  • News & Views |

    New studies suggest that NKG7 is essential for NK and CD8+ T cell cytotoxic degranulation and CD4+ T cell activation and proinflammatory responses. While the mechanism is yet to be determined, the functional relevance is exciting and opens the possibility of a new target for cellular immunotherapies.

    • Subramaniam Malarkannan
  • News & Views |

    The combination of single-cell RNA-seq and in vivo CRISPR–Cas9 screens reveal a new circuit that directs germinal center B cells toward a memory B cell phenotype during viral infection.

    • Kim L. Good-Jacobson
    •  & Joanna R. Groom
  • News & Views |

    Group 2 innate lymphoid cells (ILC2s) closely intersect with antitumor immunity. A new study describes how activation of lung-resident ILC2s orchestrates the suppression of natural killer cell–mediated innate antitumor immunity via an eosinophil-mediated metabolic mechanism.

    • Haiming Wei
    •  & Binqing Fu
  • News & Views |

    Durable responses to immunotherapy require the development of robust CD8+ T cell memory. A new study indicates that NRP1 differs from other checkpoint receptors as it functions as a checkpoint for the generation of memory.

    • Nandini Acharya
    •  & Ana C. Anderson
  • News & Views |

    A complex formed by the chemokine CXCL10 and commensal skin microbiota–derived DNA is a crucial component that triggers type I IFN responses to facilitate skin repair.

    • Vinod Nadella
    •  & Keisuke Nagao
  • News & Views |

    Guanylate-binding proteins (GBPs) promote immune defenses against infectious agents. Two studies reveal that GBP1 directly binds to cytosolic lipopolysaccharide (LPS), bringing caspase-4 to the surface of bacteria to induce pyroptosis.

    • Shouya Feng
    •  & Si Ming Man
  • News & Views |

    Antigen escape by solid tumors has limited the efficacy of genetically modified T cells. T cells engineered to secrete the cytokine Flt3L induce the activation of endogenous T cells, enabling a broader repertoire of tumor antigens to be targeted via the expansion of intratumoral antigen presenting cells, significantly improving tumor responses.

    • Emma C. Morris
  • News & Views |

    CAR T cells are engineered to recognize tumor-specific antigens and kill tumor cells. A study of CAR T cell activation using single-molecule microscopy reveals that CARs fail to efficiently convert antigen binding into early T cell signaling events.

    • Björn F. Lillemeier
  • News & Views |

    Quantitative systems-level proteomics is cleverly used to reveal a dynamic program of protein turnover in naive and memory CD4+ T cells that, alongside a stockpile of metabolic protein machinery, poises the cells for activation.

    • Julia M. Marchingo
    •  & Doreen A. Cantrell
  • Comment |

    In October 2005, we, alongside the laboratory of Casey Weaver, identified a third type of helper T cells that produce the cytokine IL-17, important for the regulation of tissue inflammation.

    • Chen Dong
  • Comment |

    Laurie Glimcher and colleagues recount their work that showed how the transcription factor XBP1 and the UPR signaling pathway are interconnected during plasma cell differentiation.

    • Laurie H. Glimcher
    • , Ann-Hwee Lee
    •  & Neal N. Iwakoshi
  • News & Views |

    Evolutionary genetic and experimental analyses suggest that mutations causing familial Mediterranean fever have been positively selected in the Middle East, probably because they confer heightened resistance against Yersinia pestis infection.

    • Etienne Patin
  • Editorial |

    Twenty years ago, a new immunology journal was launched. The editors now celebrate the anniversary of Nature Immunology by looking at the past, present and future.

  • Comment |

    Paola Ricciardi-Castagnoli describes how her groups’ focus on mucosal immunity led to the discovery of how dendritic cells sense the gut microbiota to maintain homeostasis.

    • Paola Ricciardi-Castagnoli
  • Comment |

    Takashi Fujita’s discovery of RNA helicases as intracellular viral replication sensors illustrates how scientific knowledge develops in logical — and sometimes illogical — ways.

    • Takashi Fujita
  • Comment |

    Nature Immunology’s 20th anniversary is a good opportunity to reminisce about the ImmGen collective endeavor — its goals, successes and horror stories — and the group’s exploration of various modes of scientific publishing.

    • Stephanie Vargas Aguilar
    • , Oscar Aguilar
    • , Rhys Allan
    • , El Ad David Amir
    • , Veronique Angeli
    • , Maxim N. Artyomov
    • , Natasha Asinovski
    • , Jilian Astarita
    • , K. Frank Austen
    • , Geetika Bajpai
    • , Nora Barrett
    • , Alev Baysoy
    • , Christophe Benoist
    • , Angelique Bellemare-Pelletier
    • , Brad Berg
    • , Adam Best
    • , Natalie Bezman
    • , David Blair
    • , Julie M. Blander
    • , Milena Bogunovic
    • , Patrick Brennan
    • , Michael Brenner
    • , Brian Brown
    • , Matthew Buechler
    • , Jason Buenrostro
    • , Maria Acebes Casanova
    • , Kyunghee Choi
    • , Andrew Chow
    • , Aleksey Chudnovskiy
    • , Daniela Cipoletta
    • , Nadia Cohen
    • , James J. Collins
    • , Marco Colonna
    • , Alison Cook
    • , James Costello
    • , Viviana Cremasco
    • , Ty Crowl
    • , Karine Crozat
    • , Richard Cruse
    • , June D’Angelo
    • , Marc Dalod
    • , Scott Davis
    • , Cagatay Demiralp
    • , Tianda Deng
    • , Jigar V. Desai
    • , Fiona Desland
    • , Maxime Dhainaut
    • , Jiarui Ding
    • , Andrew Doedens
    • , Claudia Dominguez
    • , Graeme Doran
    • , Regine Dress
    • , Michael Dustin
    • , Daniel Dwyer
    • , Ivan Dzhagalov
    • , Kutlu Elpek
    • , Ayla Ergun
    • , Jeff Ericson
    • , Eunice Esomonu
    • , Keke Fairfax
    • , Anne Fletcher
    • , Michela Frascoli
    • , Anja Fuchs
    • , Anastasiia Gainullina
    • , Shani Gal-Oz
    • , Michael Gallagher
    • , Emmanuel Gautier
    • , Roi Gazit
    • , Sophie Gibbings
    • , Matthieu Giraud
    • , Florent Ginhoux
    • , Ananda Goldrath
    • , Dagmar Gotthardt
    • , Daniel Gray
    • , Melanie Greter
    • , Ricardo Grieshaber-Bouyer
    • , Martin Guilliams
    • , Sara Haidermota
    • , Randy Hardy
    • , Daigo Hashimoto
    • , Julie Helft
    • , Deborah Hendricks
    • , Tracy Heng
    • , Jonathan Hill
    • , Gordon Hyatt
    • , Juliana Idoyaga
    • , Claudia Jakubzick
    • , Jessica Jarjoura
    • , Daniel Jepson
    • , Baosen Jia
    • , Radu Jianu
    • , Tim Johanson
    • , Stefan Jordan
    • , Vladimir Jojic
    • , Stefan Jordan
    • , Yosuke Kamimura
    • , Veronica Kana
    • , Joonsoo Kang
    • , Varun Kapoor
    • , Ephriam Kenigsberg
    • , Andrew Kent
    • , Charles Kim
    • , Edy Kim
    • , Francis Kim
    • , Joel Kim
    • , Kiwook Kim
    • , Evgeny Kiner
    • , Jamie Knell
    • , Daphne Koller
    • , Larry Kozinn
    • , Karen Krchma
    • , Taras Kreslavsky
    • , Mitchell Kronenberg
    • , Wing-Hong Kwan
    • , David Laidlaw
    • , Viola Lam
    • , Lewis Lanier
    • , Catherine Laplace
    • , Caleb Lareau
    • , Yonit Lavin
    • , Kory J. Lavine
    • , Andrew Leader
    • , Marylene Leboeuf
    • , Jacob Lee
    • , Jisu Lee
    • , Bo Li
    • , Hu Li
    • , Yuesheng Li
    • , Michail S. Lionakis
    • , Herve Luche
    • , Lydia Lynch
    • , Assaf Magen
    • , Barbara Maier
    • , Deepali Malhotra
    • , Nidhi Malhotra
    • , Marie Malissen
    • , Alexandra Maslova
    • , Diane Mathis
    • , Adelle McFarland
    • , Miriam Merad
    • , Etienne Meunier
    • , Jennifer Miller
    • , Justin Milner
    • , Michael Mingueneau
    • , Gundula Min-Oo
    • , Paul Monach
    • , Devapregasan Moodley
    • , Arthur Mortha
    • , Maelig Morvan
    • , Sara Mostafavi
    • , Soren Muller
    • , Christoph Muus
    • , Tsukasa Nabekura
    • , Tata Nageswara Rao
    • , Vipin Narang
    • , Kavitha Narayan
    • , Hadas Ner-Gaon
    • , Quyhn Nguyen
    • , Peter A. Nigrovic
    • , German Novakovsky
    • , Stephan Nutt
    • , Kayla Omilusik
    • , Adriana Ortiz-Lopez
    • , Helena Paidassi
    • , Henry Paik
    • , Michio Painter
    • , Mallory Paynich
    • , Vincent Peng
    • , Marc Potempa
    • , Rachana Pradhan
    • , Jeremy Price
    • , Yilin Qi
    • , Yiqing Qi
    • , Sara Quon
    • , Ricardo Ramirez
    • , Deepshika Ramanan
    • , Gwendalyn Randolph
    • , Aviv Regev
    • , Andrew Rhoads
    • , Michelle Robinette
    • , Samuel Rose
    • , Derrick Rossi
    • , Katie Rothamel
    • , Ravi Sachidanandam
    • , Priyanka Sathe
    • , Charlotte Scott
    • , Kumba Seddu
    • , Peter See
    • , Alexey Sergushichev
    • , Laura Shaw
    • , Tal Shay
    • , Avishai Shemesh
    • , Susan Shinton
    • , Justin Shyer
    • , Michael Sieweke
    • , Chris Smillie
    • , Lotte Spel
    • , Nick Spidale
    • , Giuseppina Stifano
    • , Ayshwarya Subramanian
    • , Joseph Sun
    • , Katelyn Sylvia
    • , Julie Tellier
    • , Sébastien This
    • , Elena Tomasello
    • , Helena Todorov
    • , Shannon Turley
    • , Brinda Vijaykumar
    • , Amy Wagers
    • , Ei Wakamatsu
    • , Chendi Wang
    • , Peter L. Wang
    • , Aleksandra Wroblewska
    • , Jun Wu
    • , Edward Yang
    • , Liang Yang
    • , Aldrin Yim
    • , Lim Sheau Yng
    • , Hideyuki Yoshida
    • , Bingfei Yu
    • , Yan Zhou
    • , Yanan Zhu
    •  & Caroline Ziemkiewicz
  • News & Views |

    CXCR3+ regulatory T cells, known to limit type 1 immune responses, can promote tissue-resident immunity by providing bioactive transforming growth factor-β to CD8+ T cells.

    • Nicole Joller
  • News & Views |

    Caspase-cleaved gasdermin D forms pores in cellular membranes, thus executing proinflammatory cell death by pyroptosis. Disulfiram — a drug used to treat chronic alcoholism — is now found to be an inhibitor of pore formation, which may therapeutically counteract exacerbated inflammation in sepsis and beyond.

    • Florian I. Schmidt
    •  & Eicke Latz
  • News & Views |

    The identification of the acute phase protein serum amyloid A as a soluble allergen sensor sheds new light on the mechanisms involved in the induction of type II airway inflammation.

    • Rudi W. Hendriks
  • News & Views |

    A new report finds that peripheral immunization generates tissue-resident memory CD8+ T cells in the central nervous system that provide robust protection against local infection.

    • Michael A. Kovacs
    •  & Tajie H. Harris
  • News & Views |

    Host cell cholesterol is often exploited by pathogens for entry and egress. Two new studies elucidate a new interferon-inducible mechanism by which cells limit plasma membrane cholesterol to promote antibacterial defense.

    • Eric V. Dang
    • , Hiten D. Madhani
    •  & Russell E. Vance
  • News & Views |

    B cells undergo iterative rounds of somatic hypermutation and selection for high-affinity antigen binding in the germinal center microenvironment. Two new studies provide insights into the temporal and spatial control mechanisms that act within B cells and follicular dendritic cells to jointly govern B cell differentiation and cell traffic within the GC.

    • Jagan R. Muppidi
    •  & Ulf Klein
  • News & Views |

    Injury or infection renders patients vulnerable to secondary pneumonia. A new study indicates that SIRP-α triggers prolonged impairment of the phagocytic capacity of alveolar macrophages after the resolution of primary bacterial or viral pneumonia.

    • Alex F. de Vos
    •  & Tom van der Poll
  • Comment |

    Immunologists used to avoid metabolism, but that is no longer possible. Now that we must talk about it, how can we do so in a way that enhances and clarifies our understanding of the role metabolism plays in the immune response?

    • Michael P. Murphy
    •  & Luke A. J. O’Neill
  • Research Highlight |

    • Zoltan Fehervari
  • News & Views |

    Myeloid-derived suppressor cells (MDSCs) occupy sites of chronic inflammation and suppress CD8+ T cell function. A new study describes the transfer of the metabolite methylglyoxal (MG) to T cells, which mediates this immunosuppressive mechanism.

    • Vijyendra Ramesh
    •  & Jason W. Locasale