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How chemokines invite leukocytes to dance

Nature Immunology volume 9, pages 953–959 (2008)Cite this article

Abstract

A prominent activity of the chemokine system is the regulation of leukocyte trafficking. Here we summarize recent findings on the initial steps in chemokine receptor–induced signal transduction in leukocytes. In particular, we discuss the potential influences of the formation of oligomers of ligand and receptor and of coupling between chemokine signals and regulators of the cytoskeleton, such as small GTPases.

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Figure 1: Stages of CCL19-induced T cell polarization.
Figure 2: Early and late intracellular signaling modules that lead to the polarization and migration of naive T cells.

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Acknowledgements

We apologize to colleagues whose work we were unable to cite because of space constraints. Supported by the Helmut Horten Foundation (M.T.), the Swiss National Science Foundation (M.T. and J.V.S.), the European Union Sixth Framework Programme (INNOCHEM; LSHB-CT-2005-518167 to M.T.; MEXT-CT-2005-025405 to J.V.S.) and the Swiss State Secretariat for Education and Research (J.V.S.)

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  1. Institute for Research in Biomedicine, Via Vincenzo Vela 6, Bellinzona, CH-6500, Switzerland

    Marcus Thelen

  2. Theodor Kocher Institute, University of Bern, Freiestrasse 1, Bern, CH-3012, Switzerland

    Jens V Stein

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Thelen, M., Stein, J. How chemokines invite leukocytes to dance. Nat Immunol 9, 953–959 (2008). https://doi.org/10.1038/ni.f.207

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  • DOI: https://doi.org/10.1038/ni.f.207

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