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Long non-coding RNAs contribute to the regulation of gene expression. Crooks and colleagues profile the long non-coding RNA transcriptome during the specification and development of human lymphocytes.
Proteomic profiling can provide new insight into the cellular regulation of effector functions. Cantrell and colleagues report discordant mRNA profiles and protein profiles in activated CD8+ T cells and reveal new roles for mTORC1 in regulating the function of cytotoxic T lymphocytes.
The process of B cell differentiation into plasma cells involves dramatic cellular reprogramming. Corcoran and colleagues profile the transcriptome of all stages of B cell differentiation through to antibody-secreting plasma cells.
The classification of some subsets of innate lymphoid cells (ILCs) is unclear. Colonna and colleagues use transcriptional profiling to show unique gene-expression patterns for some ILCs and overlapping patterns between ILC1 and NK cells.
Long intergenic noncoding RNAs (lincRNAs) contribute to the regulation of gene expression. Pagani and colleagues identify hundreds of unique lincRNAs expressed in human lymphocytes and demonstrate a role for the lincRNA linc-MAF-4 in the differentiation of CD4+ T cells.