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The authors recount their discovery of how pathogen-induced interleukin 12 production leads to TH1 T cell polarization. Simultaneously they discovered the suppressive cytokine interleukin 10 inhibits antigen-presenting cells, thus regulating development of TH1 cells.
Jan Vilcek relates how his work helped to identify some of the pleiotropic actions of tumor necrosis factor and contributed to the development of infliximab, the first medically useful tumor necrosis factor antagonist.
Anjana Rao recounts the contributions of two talented and productive postdoctoral fellows who purified and characterized the transcription factor NFAT.