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Volume 48 Issue 9, September 2016

Volume 48 Issue 9

Cover Art: Cerealists by Rachel Meyer

Editorial

  • Editorial |

    The coevolution of staple crops and human society can be traced in the relics of ancient genomes and in population genetic signatures that our interdependence has left on our genomes and those of our crop plants. Patterns of geographical adaptation in the genomes of local crop varieties connect millennia of survival strategies of subsistence farmers with future agricultural improvement in the face of challenges from environmental changes.

Correspondence

News & Views

  • News & Views |

    A new analysis has characterized a fundamental building block of complex transcribed loci. Constellations of core promoters can generally be reduced to pairs of divergent transcription units, where the distance between the pairs of transcription units correlates with constraints on genomic context, which in turn contribute to transcript fate.

    • Craig D Kaplan
  • News & Views |

    A genome-wide study in Samoans has identified a protein-altering variant (p.Arg475Gln) in CREBRF as being associated with 1.3-fold increased risk of obesity and, intriguingly, 1.6-fold decreased risk of type 2 diabetes. This variant, which is common among Samoans (minor allele frequency = 26%) but extremely rare in other populations, promotes fat storage and reduces energy use in cellular models.

    • Ruth J F Loos
  • News & Views |

    Study of the Greater Middle East (GME), home to approximately 10% of the world's population, has made invaluable contributions to the characterization of rare genetic disease, especially recessive conditions arising from the tradition of consanguinity and large families with multiple children. A new study now reports 1,111 unrelated exomes from the GME and provides a comprehensive view of genetic variation for enhanced discovery of disease-associated genes.

    • Tayfun Özçelik
    • Onur Emre Onat

Analysis

Article

Letter

Technical Report

  • Technical Report |

    Victoria Hore, Jonathan Marchini and colleagues present a method for multiple-tissue gene expression studies aimed at uncovering gene networks linked to genetic variation. They apply their method to RNA sequencing data from adipose, skin and lymphoblastoid cell lines and identify several biologically relevant gene networks with a genetic basis.

    • Victoria Hore
    • Ana Viñuela
    • Jonathan Marchini

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