Study of the Greater Middle East (GME), home to approximately 10% of the world's population, has made invaluable contributions to the characterization of rare genetic disease, especially recessive conditions arising from the tradition of consanguinity and large families with multiple children. A new study now reports 1,111 unrelated exomes from the GME and provides a comprehensive view of genetic variation for enhanced discovery of disease-associated genes.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
The diagnostic yield, candidate genes, and pitfalls for a genetic study of intellectual disability in 118 middle eastern families
Scientific Reports Open Access 07 November 2022
-
A missense mutation in TRAPPC6A leads to build-up of the protein, in patients with a neurodevelopmental syndrome and dysmorphic features
Scientific Reports Open Access 01 February 2018
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Scott, E.M. et al. Nat. Genet. 48, 1071–1076 (2016).
Özçelik, T. et al. Nat. Genet. 42, 641–645 (2010).
Francke, U. et al. Am. J. Hum. Genet. 37, 250–267 (1985).
Hall, J.M. et al. Science 250, 1684–1689 (1990).
Orkin, S.H. Cell 47, 845–850 (1986).
McClellan, J. & King, M.C. Cell 141, 210–217 (2010).
Gulsuner, S. et al. Cell 154, 518–529 (2013).
Dal, G.M. et al. J. Med. Genet. 51, 455–459 (2014).
Cohen, J.C. et al. Science 305, 869–872 (2004).
Unal Gulsuner, H. et al. Proc. Natl. Acad. Sci. USA 111, 18285–18290 (2014).
Ricciardone, M.D. et al. Cancer Res. 59, 290–293 (1999).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Özçelik, T., Onat, O. Genomic landscape of the Greater Middle East. Nat Genet 48, 978–979 (2016). https://doi.org/10.1038/ng.3652
Published:
Issue Date:
DOI: https://doi.org/10.1038/ng.3652
This article is cited by
-
The diagnostic yield, candidate genes, and pitfalls for a genetic study of intellectual disability in 118 middle eastern families
Scientific Reports (2022)
-
A missense mutation in TRAPPC6A leads to build-up of the protein, in patients with a neurodevelopmental syndrome and dysmorphic features
Scientific Reports (2018)
-
Incidental and clinically actionable genetic variants in 1005 whole exomes and genomes from Qatar
Molecular Genetics and Genomics (2018)
-
al mena: a comprehensive resource of human genetic variants integrating genomes and exomes from Arab, Middle Eastern and North African populations
Journal of Human Genetics (2017)